Volume 5, number 1
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Synthesis and Analgesic Activity of 1-(1-((Substituted) Methyl)-5- Methoxy-2-Oxoindolin-3-Ylidene)-4- (Substituted Pyridin-2-Yl)Thiosemicarbazide

M. Vijey Aanandhi1*, Shiny George1 and V. Vaidhayalingam2

1Department of Pharmaceutical Chemistry, Vel’s College of Pharmacy, Chennai - 600 117 India.

2Department of Pharmaceutical Chemistry, Madras Medical College, Chennai - 600 003 India.

ABSTRACT: Some novel Mannich base isatin derivatives were synthesized by reacting 1-(5-methoxy-2-oxoindolin-3-ylidene)-4-(substituted pyridin-2-yl)thiosemicarbazide with formaldehyde and several secondary amines. Their chemical structure was elucidated by means of spectral (FT-IR, 1H NMR and mass) analysis. Investigation of analgesic activity of synthesized compounds was done by acetic acid induced writhing reflex method using diclofenac sodium as standard drug. The synthesized compounds showed significant analgesic activity.

KEYWORDS: Isatin; Schiff base; Mannich base; analgesic activity

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Aanandhi M. V, George S, Vaidhayalingam V. Synthesis and Analgesic Activity of 1-(1-((Substituted) Methyl)-5- Methoxy-2-Oxoindolin-3-Ylidene)-4- (Substituted Pyridin-2-Yl)Thiosemicarbazide. Biosci Biotechnol Res Asia 2008;5(1)
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Aanandhi M. V, George S, Vaidhayalingam V. Synthesis and Analgesic Activity of 1-(1-((Substituted) Methyl)-5- Methoxy-2-Oxoindolin-3-Ylidene)-4- (Substituted Pyridin-2-Yl)Thiosemicarbazide. Biosci Biotechnol Res Asia 2008;5(1). Available from: https://www.biotech-asia.org/?p=6843

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