Influence of Momordica charantia in physical properties and release profile of curcumin formulations

S. M. Habibur Rahman¹*, Chungath Thomas Telny² and S. kuppusamy³

¹Department of Pharmaceutics, PSG College of Pharmacy, peelamedu, Coimbatore India.

²Department of Pharmaceutical Analysis, St. James College of Pharmacy, Chalakudy India.

³Department of Pharmaceutics, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore India.

Corresponding Author E-mail: Hablet1@gmail.com

ABSTRACT: The goddess of curcumin gives color to life. Drug delivery approaches yet to be carried out to achieve the therapeutic benefit of phytoconstituent. Most of the herbal formulations emerging in the market are combination of phytomolecules1. Present study carried out to study the effect of Momordica charantia in curcumin formulation. Curcumin and Momordica charantia combination was widely used as anti-diabetic formulation. This combination is formulated as sustained release matrix tablets using HPMC and Ethyl cellulose by direct compression method. Formulated tablets were subjected to various in vitro evaluations; novel spectrophotometric method was developed and validated to quantify the Momordica charantia in the formulations.2 All formulation showed acceptable pharmacotechnical properties with excellent flow properties, in vitro release studies suggest that incorporation of Momordica charantia in curcumin formulations has no significant influence in the release profile. To conclude, the momordica charantia can be incorporated in curcumin formulations for its synergistic activity, in vivo studies can be carried out to claim the therapeutic effectiveness of the formulations.

KEYWORDS: Momordica charantia; Curcumin

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