The Impact of Concurrency of Colchicine and Simvastatin on Variation of Serum Immunoglobulins IgG, IgE, IgM and IgA in Mustard Gas-Wounded Patients

Ali Emad* and Ali koushki

Department of Internal Medicine, Section of Pulmonary Diseases, Shiraz University of Medical Sciences, Shiraz, Iran.

DOI : http://dx.doi.org/10.13005/bbra/2003

ABSTRACT: Mustard gas as a chemical weapon causes devastating effects on different tissues of the body and there is no perfect antidote against it. This gas is a very strong and non-specific alkaline agent that is capable of causing inflammation as well as increase of immunoglobulins in the patients. This gas causes irreparable and sever damage to all the body tissues; so finding of effective medicines to treat the mustard gas-exposed patients is of great importance and is the main purpose of this study. This study was conducted as double-blind intervention during 2 months. The population society was consisted of 40 mustard gas-wounded patients. Their illness had previously been approved by Foundation of Oppressed and the Crippled and other valid government agencies. These patients were referred as OPD for treatment to pulmonary clinic related to Shiraz University of Medical Sciences (Motahari, Imam Reza and Shahid Faghihi Clinics). The studied patients in this study were divided into two groups: 1- The placebo group that included 20 patients who did not receive colchicine and simvastatin. 2- The medication group included 20 patients who received simultaneously colchicine and simvastatin with daily dosage of 1 mg/d and 10 mg/d, respectively. Then blood samples were obtained from the under studied patients and the concentration of serum immunoglobulins IgG, IgE, IgM and IgA was measured by PFT method and using Prestige 24i automate analyzer device in before and after the beginning of the treatment. The results showed that there is no significant relationship between the concentrations of IgG, IgE, IgM and IgA before and after receiving the medicines and placebo (p value: 1). The obtained results from this study indicates that both colchicine and simvastatin are not effective in patients with mustard gas toxicity and thereby it will be possible to cut the treatment with both medicines in these patients and to reduce by this way the costs related to the treatment of these patients and to ignore the continues of an useless treatment.

KEYWORDS: Colchicine, Simvastatin, Immunoglobulin, Mustard Gas

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