The Relationship Between Cholestryl Ester Transfer Protein Taq I Genotype and Plasma Level of HDL Subgroups in Coronary Heart Disease

Sadegh Hasannia, Shirin Jalili and Reyhaneh Sariri*

Department of Biology, The University of Guilan, Rasht Iran.

ABSTRACT: Cholesteryl ester transfer protein (CETP) catalysis the exchange of triglycerides (TG) and cholesterol esters among plasma lipoproteins. It has been shown that variations at CETP locus is important in the levels and activity of CETP and high density lipoprotein (HDL) plasma concentration. In this research, we assessed the relationship between TaqIB CETP polymorphism and high density lipoprotein-cholestrol (HDL-C) concentration in a study sample of 128 Iranian residents. 1Based on our investigations, it was shown that presence of B1B1 genotype related to TaqIB polymorphism was negatively correlated with HDL-C and HDL2-C, but positively correlated with LDL-C. On the other hand, no correlation with HDL3-C was observed. Analysis of HDL-C subfraction in CHD and control subjects revealed that variation of the CETP TaqI B locus was significantly associated with concentration of HDL2-C subclass. Homozygous and heterozygous carried the B2 alleles, compared with B1 homozygote had significantly elevated concentration of cholesterol distribution in HDL. We concluded that variation at the CETP gene locus is a significant determinant of HDL-C levels and CETP activity. Moreover, these effects appear to translate into a lower CHD risk among patients with B2 allele.

KEYWORDS: Cholesteryl ester transfer protein;  Gene Polymorphisms;  HDL-C; Taq1B; RFLP

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