Assessment of Hepatocellular Protection and Cellular Inhibition Potential of Ficus Carica In 50% Methanolic Leaf Extract

Huma Ali¹*, N. Ganesh¹, J. D. Ahi², Megha Jha¹ H. N. Chandel³ and Ashish Maniguha¹

¹Department of Research Jawaharlal Nehru Cancer Hospital& Research Center, Idgah Hills, Bhopal - 462 001 India.

²Department of Zoology, Dr. Hari Singh Gaur University, Sagar India.

³Department of Pharmacy TRUBA College of Pharmacy Bhopal India.

ABSTRACT: Paracetamol induced a significant elevation of levels of serum marker enzymes; SGOT, SGPT, SALP and total Bilirubin. The 50 % methanolic extract of Ficus carica protects liver tissues against oxidative damages and could be used an effective protector against paracetamol induced hepatic damage. In present study 50% methanolic extract of Ficus carica against paracetamol induced hepatic disorders in mice. Results suggest that the extract possess protective action against hepatic dysfunction induced by the potent toxin, paracetamol. Data showed that the extract responds in both dose and time dependent manner. Administration of 50% methanolic extract of Ficus carica of during paracetamol intoxication prevent the CC14 induced increased levels of serum marker enzymes SGOT, SGPT, SALP and total Bilirubin.

KEYWORDS: Hepatocellular protection; Ficus carica; methanolic leaf extract

[ HTML Full Text]