Volume 5, number 2
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UV and Two Derivative Spectrometric Methods for Determination of Racecadotril in Tablet Formulation

Ch.Narasimha Raju Bh1, G. Devala Rao2 and Ramanjaneyulu Sikharam3

1A.S.N Pharmacy College, Burripalem Road, Tenali - 522 201 India.

2KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada - 520 010 India.

3St. Ann’s College of Pharmacy, Chirala India.

ABSTRACT: UV, second and third derivative spectrophotometric methods have been developed for the determination of Racecadotril in pharmaceutical formulation. The solutions of standard and sample were prepared in Methanol. For the first method, UV spectrophotometry, the quantitative determination of the drug was carried at 23l nm and the linearity range was found to be 8-100ug/ml.For the second and third derivative spectrophotometric methods the drug was determined at 250nm and 240nm with linearity ranges for both 8-100ug/ml .The calibration graphs constructed at their wavelength of determination were found to be linear for UV and derivative spectrophotometric methods. All the proposed methods have been extensively validated. The described methods can be readily utilized for the analysis of pharmaceutical formulation.

KEYWORDS: UV spectophotometry; derivative spectrophotometry; Racecadotril

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Raju Bh C.N, Rao G.D Sikharam.R. UV and Two Derivative Spectrometric Methods for Determination of Racecadotril in Tablet Formulation. Biosci Biotechnol Res Asia 2008;5(2).
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Raju Bh C.N, Rao G.D Sikharam.R. UV and Two Derivative Spectrometric Methods for Determination of Racecadotril in Tablet Formulation. Biosci Biotechnol Res Asia 2008;5(2). Available from:

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