Silver Nanoweapons: A novel Tool against Multidrug Resistant Bacteria

Hussam H. Arafat^1,3*, Mohammed H. El-Sayed¹ and Askora A.²

¹Department of Biology, Faculty of Science and Arts, Northern Border University, Rafha, KSA. ²Department of Botany, Faculty of Science, Zagazig University, Zagazig City- 44519, Egypt. ³Department of Botany and Microbiology, Faculty of Science, Minia University, Minia City- 61519, Egypt. Corresponding Authors Email: Hussamhassan77@yahoo.co.uk

DOI : http://dx.doi.org/10.13005/bbra/2009

ABSTRACT: Antibacterial activities of Ag-NPs have received much attention due to their effective killing and cost-effectiveness. Biosynthesis is an attractive and eco-friendly method to produce silver nanoparticles (Ag-NPs). Ag-NPs are considered a promising tool to overcome the emergence of multi-drug resistant bacteria. In this study, bio-synthesis of Ag-NPs was attempted using plant extracts of peppermint. Characterization of Ag-NPs was achieved by UV-visible spectrophotometer and TEM. Monodispersed Ag-NPs were obtained with different sizes ranged from 6 to 88 nm. Antibacterial activities of Ag-NPs against pathogenic bacteria were evaluated using disc diffusion method.Our results indicated that Gram positive bacteria were more susceptible than Gram negative. The current study offers a cost-effective and eco-friendly method for biosynthesis of potent bactericidal Ag-NPs and their use against human pathogenic bacteria.

KEYWORDS: silver nanoparticles; pathogenic bacteria; green synthesis; silver nanoweapons

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