Study of the mutagenic effect of tenoxicam and antimutagenic properties of ginger plant extract on root tips of Vicia faba

E. S. Ahmed¹ and N. H. Al-Twaty²    

¹Cell Biology Department, National Research Center, Dokki, Giza; ²Biology Department, King Ab Dul Aziz University, Jeddah (Saudi Arabia).

ABSTRACT: In the present study the genotoxicity of tenoxicam the anti-inflammatory drug and ginger plant extract were investigated. Determination of the ability of antigenotoxicity of ginger plant extract through the combination with the tenoxicam on mitotic division in root tips of Vicia faba plant was carried out. In this study the meristematic cells of Vicia faba were treated by tenoxicam and ginger plant extract singly or combined with three different concentrations (10-20 and 40 mg/L DH2O) for three different times (6-12-24 hours). In this study, the percentage of mitotic index decreased in single and combined treatments of tenoxicam at the highest concentration during different exposure periods. Also, tenoxicam in all concentrations and exposure periods singly or combined with ginger extract led to an increase of mutations frequency and chromosomal aberrations which included stickiness, fragments, breakage, bridges, lagging, disturbance, and micronuclei. These results suggested that tenoxicam drug singly or combined with ginger extract was found to induce chromosomal aberrations in root tip cells of Vicia faba and ginger plant extract failed to induce any mutagenis and antimutagenicity of tenoxicam drug in Vicia faba.

KEYWORDS: Tenoxicam; antimutagenic properties;Vicia faba

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