Determination of mirtazapine in tablet dosage forms by visible spectrophotometry

Ravi Kumar¹, V. Naga Lakshmi¹, S. V. M.Vardhan^2and C. Rambabu³  

¹Department of Chemistry, Acharya Nagarjuna University Nuzvid Campus, Nuzvid India.

²Department of Biochemistry, Acharya Nagarjuna University Nuzvid Campus, Nuzvid India.

³Department of Chemistry, Acharya Nagarjuna University Nuzvid Campus, Nuzvid India.

ABSTRACT: Two visible spectrophotometric methods have been developed for the quantitative estimation of Mirtazapine from its tablet formulations. The first method (method-A) is based on internal salt formation of red to violet colored chromogen of drug with citric acid – acetic anhydride which shows lmax at 580nm and linearity was observed in the concentration range of 8-40 μg.mL-1. The percentage recovery of drug from tablet formulation using this method was found to be in the range of 99.50-99.83 %. The second developed method (method-B) based on redox reaction of drug with Fe (III) – hexacyano ferrate (III) which shows lmax at 740 nm and linearity was observed in the concentration range of 5-25 μg.mL-1. The percentage recovery of drug from tablet formulation using this method was found to be in the range of 99.15-99.91 % Analysis of results for both developed methods were validated statistically. Recovery study results were close to 100%. The developed methods were found to be simple, rapid, accurate and repro9ducible. Both the methods are suitable for the estimation of mirtazapine from tablet dosage forms.

KEYWORDS: Mirtazapine;hexacyanoferrate(III)

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