Volume 6, number 2
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Process Optimization of Pantoprazole Sodium Enteric Coated Tablets

V. Ravichandhran

Department of Pharmaceutics,Vels College of Pharmacy, Pallavaram, Chennai India.

Corresponding Author E-mail: sen03mpharm@gmail.com

ABSTRACT: Pantoprazole is proton pump inhibitor, which prevent the production of acid in the stomach. Pantoprazole sodium enteric coated tablets were prepared by direct compression method. During this study the process parameters like granulation process, Compression process and Coating process are optimized by conducting the study with various blending time, blending speed, compression machine speed, pan speed, spray rate, spray gun distance to tablet bed, atomizing air pressure. Based on the evaluation results of various trials the optimum process parameters are selected (bending time-23min,blending speed- 6rpm, compression speed-30rpm, pan speed-9rpm, spray rate- 70ml/gun/min, spray gun distance to tablet bed- 24cm and atomizing air pressure-6kg/cm2). By using this optimized parameters the final batch was prepared it was subjected to evaluation. The results are correlated with the standard specified limits.

KEYWORDS: pantoprazole sodium; process optimization; Granulation process; Compression process

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Ravichandhran. V. Process Optimization of Pantoprazole Sodium Enteric Coated Tablets. Biosci Biotechnol Res Asia 2009;6(2)
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Ravichandhran. V. Process Optimization of Pantoprazole Sodium Enteric Coated Tablets. Biosci Biotechnol Res Asia 2009;6(2). Biosci Biotechnol Res Asia 2009;6(2). Available from: https://www.biotech-asia.org/?p=8736.

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