Volume 6, number 2
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Formulation and Evaluation of Diclofenac Sodium Delayed Release Tablets

V. RavichandIran

Department of Pharmaceutics,Vels college of Pharmacy, Pallavaram, Chennai India.

Corresponding Author E-mail: sen03mpharm@gmail.com

ABSTRACT: Delayed release tablets of Diclofenac sodium tablets were prepared by wet granulation method using different pH resistant polymers like HPMC, CAP and Eudragit to dissolve it in alkaline pH. F1-F4 trials were performed and evaluated. F4 was found to be satisfactory. F4 was seal coated using HPMC E-5 EP & PEG 400L(F5). F5 was enteric coated using HPMC (F6-F7), CAP(F8-F9), EUDRAGIT (F10-F11).Dissolution was carried out in 0.1 N HCl for first 2hrs and next 1hr in phosphate buffer pH6.8. Dissolution studies of EUDRAGIT polymer trail (F10) shows much better release then HPMC and CAP.

KEYWORDS: Diclofenac sodium; Enteric coated tablets; Delayed release tablets; pH resistant polymers

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RavichandIran. V.Formulation and Evaluation of Diclofenac Sodium Delayed Release Tablets. Biosci Biotechnol Res Asia 2009;6(2)
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RavichandIran. V.Formulation and Evaluation of Diclofenac Sodium Delayed Release Tablets. Biosci Biotechnol Res Asia 2009;6(2). Available from: https://www.biotech-asia.org/?p=8869.

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