Effect of α-Tocopherol Acetate on Dexamethasone Induced Experimental Insulin Resistance-role of Oxidative Stress

V. Biradar¹*, H. Ramesh¹, M. H. Malipatil², Rajshekhar M. Bhande¹And Sanjivkumar D. Biradar¹

¹RRK’S College of Pharmacy, Bidar, Karnataka India.

²Karnataka College of Pharmacy, Bidar, Karnataka India.

ABSTRACT: Dexamethasone is widely used Immunosuppressant and Anti-inflammatory agent. Its use is associated with evolution of Insulin Resistance (IR) and Hypertension these are probably attributed to oxidative stress. In the present study, effect of Antioxidant like ?-Tocopherol (Vitamin E) was administered (100mg/kg /day, mixed in sesame oil and food pallets were soaked in it) through diet for Prophylactic aswell Therapeutic regimen in Experimental Induced Insulin Resistance by using Dexamethasone (20μg/kg /once daily, subcutaneously) for 14 days in male Wister rats (240-300g) and estimated plasma Insulin and TBARS level in plasma aswell in isolated Aortic tissue as a marker of oxidative stress. HOMA-IR index and MASTUDA INDEX were calculated as an Insulin Resistance/ Insulin sensitivity. From the finding of present study, Vitamin E Improved the Insulin sensitivity and prevented the Insulin Resistance probably due to its pleotropic effects other than Antioxidant property, so that indicate oxidative stress may not play the causative role in development of Dexamethasone Induce Insulin Resistance

KEYWORDS:

Insulin Resistance (IR); Oxidative Stress; Dexamethasone; Insulin Resistance Index (HOMA- IR)

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