Antibacterial Study and Effect on Glucoamylase in Vitro of Aqueous and Methanolic Extracts of Syzygium Cumini Seeds

G. A. Meshram , Sunil S. Yadav, Dattatray Shinde, Deepak Singh and Bhavana Patil

Department of Chemistry, Mumbai University, Mumbai - 400 098 India.  

ABSTRACT: Antibacterial and glucoamylase inhibitory effect of aqueous and methanolic extracts isolated at different temperatures from seeds of Syzygium cumini is studied in vitro. Both aqueous and methanolic extracts are antibacterial against E. coli, B. subtilis, P. aeruginosa and S. aureus. The aqueous extract isolated at 250C and methanolic extract isolated at 100C showed 35% and 50% of maximum inhibition of glucoamylase respectively. Water extracts of Syzygium cumini seed are low inhibitors of glucoamylase than methanolic extracts. We observed that water extract isolated at 25oC is moderate inhibitor of glucoamylase. Even though the extraction yield with methanol is less but inhibition of glucoamylase is greater (25 to 50%). Thus we conclude that methanolic extract of Syzygium cumini seed is potent inhibitor of glucoamylase and hence hypoglycaemic than aqueous extracts in diabetes type-2.

KEYWORDS: Syzygium cumini; Glucoamylase; Antibacterial; Glucoamylase inhibitor

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