A Study of Oxidative Stress In Preeclampsia

Chandan K. Nath¹, Mriganka Baruah², Indrajit Nath³, Upasana Baruah⁴ and Aroon Chandra Bayan⁵

¹Department of Biochemistry, NEIGRIHMS, Shillong, Meghalaya, India.

²Department of Biochemistry, Melmaruvathur Adhiparasakthi Institute of Medical Science, India.

³Department of Biochemistry, North Bengal Medical College, West Bengal, India.

⁴Department of O and G, Guwahati, Assam, India.

⁵Department of O and G, Binapani Nursing Home & Hospital, Barpeta Road, Assam, India.

Corresponding Author E-mail: drmriganka.b@gmail.com

ABSTRACT: Preeclampsia is a pregnancy specific syndrome of reduced organ perfusion secondary to vasospasm and endothelial activation. A number of reports indicate that preeclampsia is associated with elevated blood levels of lipid peroxidation products. The present study was undertaken to evaluate the metabolic correlation between preeclampsia and oxidative stress. 95 no of subjects was selected out for the study out of which normal nonpregnant control group had 25 subjects, normal pregnant control group had 40 subjects & preeclampsia group constituted of 30 subjects. The investigations included are serum lipid profile consisting of serum total cholesterol, serum triglycerides, VLDL, LDL and HDL, serum vitamin E as á- tocopherol and malondialdehyde. There is significant increase in serum triglyceride, serum cholesterol along with LDL and VLDL (p<0.0001) in pregnancy over nonpregnant controls and preeclampsia over pregnant control (p<0.0001). It is observed that in normal controls without pregnancy there is no relationship between serum vitamin E and serum lipid peroxidation as represented by whole blood MDA (malondialdehyde) with a correlation coefficient of 0.13 only. In contrast to this, under the condition of normal pregnancy and preeclampsia the correlation between these two parameters increased with coefficients of correlation (r = - 0.9) with a negative trend indicating a definite and significant degree of inverse relationship between two. It is finally proposed that adequate vitamin E supplementation during pregnancy with proportionate increase in preeclampsia may reduce the consequences of peroxidation induced complications during pregnancy.

KEYWORDS: Preecclampsia; Oxidative Stress; Malondialdehyde

[ HTML Full Text]