Effect of Trigonella Foenum Graecum (Fenugreek) on Diabetes Induced Oxidative Stress and Tissue Antioxidants in Streptozotic Diabetic Rats

Anusha Bhaskar¹, V. G. Vidhya² and T. Nithya gopinath

¹Department of Biotechnology, Dhanalakshmi Srinivasan College of Arts and Science for Women, Perambalur - 621 212 India.

²Department of Biotechnology, Faculty of Science and Humanities, SRM University, Chennai India.

Corresponding author E-mail:anushaparthiban@gmail.com

ABSTRACT: The aim of the present study was to evaluate the effect of aqueous extracts of Trigonella foenum graecum seeds and leaves and compare their effects on lipid peroxidation and the levels of antioxidant enzymes in STZ – diabetic rats. Oral administration of the extracts (both seed and leaf) was given to two different groups of rats, for 25 days. We observed that the seed extract was more efficient than the leaf extract in combating oxidative stress in the heart, pancreas and liver of the diabetic rats and it is also augmented the antioxidant enzymes – superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) which were decreased in the STZ diabetic rats. The treatments of TFG seed extract (TFGSEt) and leaf extract (TFGLEt) were compared with that of treatment with glibenclaminde (300 μg kg-1). This study clearly demonstrates that the TFGSEt is better than TFGLEt, and it seems to have more antiperoxidative activity.

KEYWORDS: Trigonella foenum graecum; Reactive oxygen species; Diabetes mellitus; Antioxidant enzymes.

[ HTML Full Text]