Volume 9, number 2

Bioactive long chain amides from Solanum schimperianum Hochst growing in Saudi Arabia

Wafaa H. B. Hassan1-2*, Mai Al-Oqail1, Mohammad S. Ahmad1 and Adnan J. Al-Rehaily1

1Pharmacognosy department, College of Pharmacy, King Saud University, 2457, Riyadh-114 51, Saudi Arabia. 2Pharmacognosy department, Faculty of Pharmacy, Zagazig University, Zagazig-445 19, Egypt.

DOI : http://dx.doi.org/http://dx.doi.org/10.13005/bbra/1037

ABSTRACT:

Phytochemical investigation of the aerial parts of Solanum schimperianum Hochst led to isolation of four compounds 1-{1-[2-(2 hydroxypropoxy) propoxy] propan-2-yloxy} propan-2-ol. (1), acetamide (2), stearamide (3) and (6E, 9E)-N,N-dimethyloctadeca-6,9-dienamide (4). Compounds 1-4 were isolated for the first time from the family solanaceae. The structure elucidation of the isolated compounds was based on careful inspection of spectral data including 1D and 2D NMR data and MS, in addition to, comparison with literatures. The extract showed strong antimicrobial activity in most of the tested microorganisms, while the compounds 1, 3 and 4 showed antimicrobial activity against Escherichia coli and Candida albican.

KEYWORDS: Solanum schimperianum; stearamide; acetamide; antimicrobial activity.

Copy the following to cite this article:

Hassan W. H. B, Al-Oqail M, Ahmad M. S, Al-Rehaily A. J. Bioactive long chain amides from Solanum schimperianum Hochst growing in Saudi Arabia. Biosci Biotech Res Asia 2012;9(2)
Copy the following to cite this URL:

Hassan W. H. B, Al-Oqail M, Ahmad M. S, Al-Rehaily A. J. Bioactive long chain amides from Solanum schimperianum Hochst growing in Saudi Arabia. Biosci Biotech Res Asia 2012;9(2). Available from: https://www.biotech-asia.org/?p=9951

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