Lantana camara; A Plant with Potential Anti-ulcerogenic Activity

Imran Kazmi^1-2, Kamran Ahmad³, Shakir Saleem³, Muhammad Afzal¹ and Firoz Anwar¹

¹Pacific University, Udaipur, Rajasthan, India.

²Siddhartha Institute of Pharmacy, Dehra Dun, Uttarakhand, India.

³Department of Pharmacology, Luqman College of Pharmacy, Gulbarga, Karnataka, India.

Corresponding author E-mail:  afzalgufran@gmail.com

DOI : http://dx.doi.org/ http://dx.doi.org/10.13005/bbra/1058

ABSTRACT:

Lantana camara (Verbenaceae) is a medicinal plant traditionally used to treat various ailments, including gastrointestinal disorders, ulcers and internal sores. In order to establish pharmacological properties of the leaf of Lantana camara, studies were performed on antiulcer activity of the plant's aqueous and ethanolic extract. The Lantana camara aqueous extract (AELC) and ethanolic extract (EELC) was prepared in the doses of 250mg/kg and 500mg/kg. Antiulcer activity of AELC and EELC was evaluated by pyloric ligation and aspirin induced ulcer models. Acute toxicity was also carried out. The AELC and EELC dose dependently showed significant antisecretory activity as evidenced by decreased gastric juice volume, free acidity, total acidity, and increase in the pH of the gastric fluid in pylorus-ligated rats. Our studies also revealed that pretreatment with AELC and EELC significantly reduced the ulcer index in pylorus-ligated and aspirin treated rats in dose dependent manner. The antiulcer activity of Lantana camara is further supported by histopathological study which showed protection of mucosal layer from ulceration and inflammation. The present findings conclude that aqueous and ethanolic extract of Lantana camara has antiulcer effects; ethanolic extract is more potent then aqueous extract of Lantana camara and justify the traditional usage of this herb to treat ulcers.

KEYWORDS: Lantana camara; Antiulcer activity;Ulcer index; Aspirin; Pylorus ligation; Histopathology.

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