Effect of Bryophyllum pinnatum Lam. on N-diethylnitrosamine Induced Hepatic Injury in Rats

Muhammad Afzal^1-2, Kamran Ahmad³, Shakir Saleem³, Imran Kazmi¹ and Firoz Anwar¹

¹Pacific University, Udaipur, Rajasthan, India.

²Siddhartha Institute of Pharmacy, Dehra Dun, Uttarakhand, India.

³Department of Pharmacology, Luqman College of Pharmacy, Gulbarga, Karnataka, India.

DOI : http://dx.doi.org/http://dx.doi.org/10.13005/bbra/1060

ABSTRACT:

Present study designed to evaluate the effect of Bryophyllum pinnatum Lam. on n-diethylnitrosamine (DENA) induced hepatic injury in rats. The aerial part of B. pinnatum aqueous and ethanolic extract was prepared in the doses of 250mg/kg and 500mg/kg. Hepatic injury was induced by DENA. Acute toxicity was also carried out. Treatment with different doses of ethanolic extract of B. Pinnatum (250 mg/kg, p.o.) not significantly able to treat the liver injury induced by DENA, but 500 mg/kg dose of ethanolic extract of B. Pinnatum slightly protect the liver. Treatment with different doses of aqueous extract of B. Pinnatum (250 and 500 mg/kg, p.o.) significantly (p*<0.05; p**<0.01 and p***<0.001) treat the liver injury induced by DENA. It may be inferred from the present study that the hepatoprotective activities of the aqueous extract of B. Pinnatum leaves in DENA-induced hepatotoxicity may involve its antioxidant or oxidative free radical scavenging activities by alleviating lipid peroxidation through scavenging of free radicals, or by enhancing the activity of antioxidants.

KEYWORDS: Bryophyllum pinnatum; N-diethylnitrosamine; Histopathology; Rats.

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