Anticonvulsant Activity of Otostegia persica (Burm.) Boiss

Farnoosh Ansari¹, Hamed Shafaroodi¹ and Jinous Asgarpanah²*

¹Department of Pharmacology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran - Iran (IAUPS). ²Department of Pharmacognosy, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran - Iran (IAUPS).

ABSTRACT: Investigation of the anticonvulsant activity Otostegia persica. The anticonvulsant activity of O. persica total extract was assessed in pentylenetetrazole (PTZ)-induced convulsion in mice, with Diazepam as standard drug. While mechanistic studies were conducted using flumazenil, a GABAA-benzodiazepine receptorcomplex site antagonist. the extractproduced protectionagainst convulsion at800mg/kg, compared with protection with benzodiazepine.The mean onset and percentage protection against convulsion in extract-treated mice werereduced by flumazenil. These results suggest that O. pesica extractpossesses biologically active constituent(s) that haveanticonvulsant activity which supports the ethnomedicinal claims of the use of the plant in the management of seizure.

KEYWORDS: Otostegia persica; Lamiaceae; Anticonvulsant activity; Clonic seizure

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