The Effect of Vitamin C as Antioxidant on the Toxic Effects Due to Deltamethrin Pesticide on Morphometric and Histopathological Parameters of ovary in the Rats

Pourdanesh Mohammad Ali¹* and Rahimi Farzaneh²

₁Department of Medical Science, Jahrom Branch, Islamic Azad University, Jahrom, Iran. ²Department of Biology, Islamic Azad University, Jahrom Branch, Jahrom, Iran.

ABSTRACT: The pesticides are the wide range of chemical compounds that have made in order to eliminate the agricultural and sanitarian pests. The objective of this study was to check the effect of Deltamethrine pesticides on Morphometric and histopathological parameters of ovary in rats. In this study, 63 adult female Wistar rats were divided into 9 groups of 7. Samples in 0.5 ml, every day at 8:00 a.m for 14 days were injected intraperitoneally. The control group received no medication. group 1 received 1 physiologic serum, group 2 received 20 mg/kg bodyweight, vitamin C, experimental groups of 1, 2 & 3 received 2.5, 5 & 10 mg/kg bodyweight doses of Deltamethrin, respectively. experimental groups of 4, 5& 6 received, 2.5, 5 & 10 mg/kg bodyweight doses of Deltamethrin respectively and 20mg/kg body weight of vitamin c. Next, histological and hormonal performed then, the data analysis statistically by ANOVA(one-way analysis of variance) and Duncane tests. In significant level, (p<0.05) was determined by SPSS software version 15. The numbers of the primary follicles in experimental groups of 1, 2 & 3 showed a significant decrease toward control group. The primary follicles in experimental group of 3 have a significant decrease. In experimental group of 2 ,3, the secondary follicles showed a significant decrease toward control group. Number of corpus Luteum also in experimental groups of 1, 2, 3, 5 and 6 have a significant decrease toward control group. The number of atresia follicles experimental group of 2 and 3 have a significant increase toward control group. The results of this study show that Deltamethrin may cause changes in morphometric and histopathological parameters of ovary in rats and vitamin c also show mild antioxidant toward the toxic effect of Deltamethrin. Thus, Deltamethrin may cause the detrimental effects on ovary tissue and somewhat vitamin c has reduced the detrimental effects.

KEYWORDS:

Deltamethrin; vitamin c; histopathology; ovary; the rat

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