Comparission Between Midazolam and Midazolam Plus Diphenhydramine Efficacy of Sedation in Children Undergoing CT-scan admitted to the Hospital in Tehran

Ali Mohammadshahi¹, Ali Omraninava¹*, Amir Masoud Hashemian² and Mohammad Mehdi Forouzanfar³

¹Department of Emergency Medicine, AJA University of Medical Sciences, Tehran, Iran ²Department of Emergency Medicine, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. ³Department of Emergency Medicine , Shohadaye Tajrish Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

ABSTRACT: Sedation is a technical administration of sedative agents that usually is associated with an analgesic drug and makes a situation to allow the patient to tolerate unpleasant procedures, however the patient’s cardiopulmonary function remains appropriate. These measures are aimed to improve the quality of care and patient satisfaction, to reduce pain and anxiety and to facilitate the success of diagnostic and therapeutic measures. In this study, the effect of the combination of oral midazolam and oral diphenhydramine with midazolam were studied and compared in CT scans only in the sedation of 48 children aged one to seven years whom their medical records were evaluated before induction and procedures for the presence of contraindication for prescribing and also had no neurologic and vascular deficits. . These individuals were monitored in terms of blood pressure, heart rate, respiratory rate and arterial oxygen saturation. Data obtained from the monitoring was interpreted and analyzed by SPSS software. Finally, it was shown that the combination of oral midazolam and oral diphenhydramine leads to a safer and more effective sedation compared with midazolam alone in children during CT scan. This combination will enable the sedation failure during CT scans for children to get the lowest rates.

KEYWORDS: Midazolam; diphenhydramine; CT-scan

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