Volume 10, number 2

Microbial Transformation of Bioactive Anthraquinones - A Review

 

Sadia Sultan1,2*, Nurunajah Ab. Ghani2,3, Syed Adnan Ali Shah1,2, Nor Hadiani Ismail2,3, Mohd Zaimi Noor1,2 and Humera Naz1,2*

 

1Department of Pharmacology and Chemistry, Faculty of Pharmacy, Universiti Teknologi MARA(UiTM) Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor D.E., Malaysia. 2Atta-ur-Rahman Institute for Natural Product Discovery (AuRIns), Level 9, FF3, Universiti Teknologi MARA (UiTM) Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor D.E., Malaysia. 3Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM), 40450 Shah Alam, Selangor D.E., Malaysia.

DOI : http://dx.doi.org/10.13005/bbra/1167

ABSTRACT:

Anthraquinones, especially hydroxyanthraquinones, constitute one of the most ubiquitous classes of naturally occurring phenolic compounds. The hydroxyl and aminoanthraquiones show diverse physiological and pharmacological activity. Since pharmacological studies of small molecule bioactive compounds are known to be hampered by their weak solubility in water, it is important to prepare water-soluble analogues of hydroxy- and aminoanthraquinones by biotransformation. This review summarizes the glucosidation of substituted anthraquinones to achieve soluble analogues using fungi.

 

KEYWORDS: Anthraquinone; biotransformation; fungi; glycoside

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Sultan S, Ghani N. A, Shah S. A. A, Ismail N. H, Noor M. Z, Naz H. Microbial Transformation of Bioactive Anthraquinones - A Review. Biosci Biotechnol Res Asia 2013;10(2)
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Sultan S, Ghani N. A, Shah S. A. A, Ismail N. H, Noor M. Z, Naz H. Microbial Transformation of Bioactive Anthraquinones - A Review. Biosci Biotechnol Res Asia 2013;10(2). Available from:https://www.biotech-asia.org/?p=10696

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