Molecular Modelling and Structure analysis of S-ribosyl homocysteinase from Aeromonas hydrophila

T.Yuvarani¹, V. Anuradha², N. Yogananth³, M. Syed Ali³ and R. Karthik⁴

¹Department of Biotechnology, D.G.Vaishnav College, Arumbakkam, Chennai -600106, India ²Department of Biochemistry, Mohamed Sathak College of Arts & Science, Sholinganallur, Chennai-600119, India ³Department of Biotechnology, Mohamed Sathak College of Arts & Science, Sholinganallur, Chennai-600119, Tamilnadu, India ⁴Department of Marine Biotechnology, AMET University, Kanathur, Chennai - 603112.

DOI : http://dx.doi.org/10.13005/bbra/1432

ABSTRACT: In the Present study, Molecular modelling and structure analysis was performed for S-ribosyl homocysteinase from Aeromonas hydrophila. This is to determine new set of compounds that can be explored as antibiotics sensing and targeting the Quorum sensing proteins. The Probable ligands and their binding sites were also determined using ligprof server. HPS[2- Amino- 4- Mercapto- Butyric acid] was found to be the best ligand which can bind to the 3D structure of the target protein.

KEYWORDS: Aeromonas hydrophila; Quorum sensing; S-ribosyl homocysteinase; AI-2 synthase; Insilico analysis

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