Sargassum Ilicifolium (Turner) C.Agardh  Ameliorate  Oxidative Stress Induced Neuronal Degeneration in the  Animal Model of Alzheimer’s Disease

Sumithra M¹, Arunachalam G² and Chitra V¹

¹SRM College of Pharmacy, SRM University, Kattankulathur. ²PGP College of Pharmaceutical Sciences and Research Institute, Namakkal. Corresponding Author Email: sumi26379@gmail.com

DOI : http://dx.doi.org/10.13005/bbra/2134

ABSTRACT: Aluminium is a neurotoxic metal, exposure leads to neurodegenerative disease like alzheimer’s. Chronic exposure to it is a real eventuality due to its presence in food, air, water, in medicines and as floculating agents in water  purification process. It is an  important task  to control its toxicity by natural source, so  the present work aimed to  investigate the   neuroprotective activity of of Sargassum ilicifolium against aluminium induction.  Aluminium chloride of dose (100mg/kg b.wt) was given orally to  induce  cognitive dysfunction in rats. The ethanolic extract and ethyl acetate fraction of dose 100, 200, 400mg/kg and 200mg/kg respectively were selected and administered from 21^st day of aluminium induction up to 40 days and in drug treated animals behavioural studies,antioxidant studies,  neurotransmitter estimation and finally histopathological studies were performed. The study has  revealed the  potential neuroprotective effect by improving the learning memory status in behavioural studies, reversing the stress induced free radicals and boosting the neurotransmitters level responsible for memory consolidation.

KEYWORDS: neuroprotective; Sargassum ilicifolium; neurodegenerative; aluminium induction

[ HTML Full Text]