Volume 13, number 3
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Serum Level of Kisspeptin in Pregnant Women with Preeclampsia

Hassan Zabetian1, Reza Sahraei1, Hossein Hakimelahi1, Alireza Yusefi1*, Mohammad Sadegh Sanie1, Saeid Sobhanian1, Abdolreza Sotoodeh Jahromi1, Abdolali Sepidkar1, Mehrnoosh Maalhagh2, Abdolhossien Madani3, Farshid Kafilzadeh4 and Mohammad Kargar4

1Research Center for Non.communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran.

2Reseach Committee, Shiraz University of Medical Sciences, Shiraz, Iran.

3Research Center for Social Determinants in Health Promotion, Hormozgan University of Medical Sciences, Bandarabbas, Iran.

4Department of biology, Jahrom branch, Islamic Azad University, Jahrom, Iran.

DOI : http://dx.doi.org/10.13005/bbra/2319

ABSTRACT: Preeclampsia is major causes of maternal and perinatal mortality and morbidity throughout the world. To diagnose preeclampsia, a large and growing number of biochemical markers have been tested as potential screening tests. Kisspeptin (KP) has recently seems as putative biomarker for preeclampsia. Therefore, the aim of study was to evaluate the sensitivity, specificity and diagnostic accuracy of KP in the second-trimester of pregnancy. This diagnostic study was conducted on 430 women in second-trimester of pregnancy. Serum concentration of KP was measured by standard sandwich enzyme-linked immune-Sorbent assay method. Sensitivity, specificity, accuracy, Likelihood ratio of a Positive and negative Test, positive and negative predictive values of the KP were calculated. Also, receiver operating characteristic (ROC) curves were used.KP mean serum level were 75.56 ± 91.76 (ng/ml) and 34.68 ± 32.86 (ng/ml) in 430 participants, respectively. Serum level of KP for diagnosis of preeclampsia in the second trimester showed that the sensitivity and specificity of the test were 33.33% and 95.36%, respectively. Diagnostic Accuracy of test was 93.27%. Positive Predictive Value and Negative Predictive Value were 20% and 97.62%, respectively. Area in ROC curve shows that possibility of diagnosing preeclampsia with KP serum level is 64.3%. To diagnose the preeclampsia in early pregnancy, KP level is a promising biomarker but regarding to inadequate test sensitivity, it cannot be recommended in screening.

KEYWORDS: kisspeptin; preeclampsia; pregnant women; screening

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Zabetian H, Sahraei R, Hakimelahi H, Yusefi A, Sanie M. S, Sobhanian S, Jahromi A. S, Sepidkar A, Maalhagh M, Madani A, Kafilzadeh F, Kargar M. Serum Level of Kisspeptin in Pregnant Women with Preeclampsia. Biosci Biotech Res Asia 2016;13(3).
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Zabetian H, Sahraei R, Hakimelahi H, Yusefi A, Sanie M. S, Sobhanian S, Jahromi A. S, Sepidkar A, Maalhagh M, Madani A, Kafilzadeh F, Kargar M. Serum Level of Kisspeptin in Pregnant Women with Preeclampsia. Biosci Biotech Res Asia 2016;13(3). Available from: https://www.biotech-asia.org/?p=15745

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