Effect of N-Acetyl Cysteine on Liver Function in General Anesthesia with Isoflurane

Bijan Yazdi¹, Alireza Jahangiri Fard², Saber Akhtaran³, Mohammad Khalili⁴ and Behnam Mahmoodiyeh^1*

¹Department of Anesthesia and Critical Care , Arak University of Medical Sciences , Arak , Iran.

²Fellowship of Cardiac Anesthesia, Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) ,Shahid Beheshti University of Medical Science, Tehran, Iran.

³Aneshtesiologist , Arak University of Medical Sciences , Arak , Iran.

⁴Department of anesthesia and critical care ,Anesthesiologist,Arak University of Medical Science , Arak ,Iran.

Corresponding Author E-mail: behnammahmoodiyeh@gmail.com

DOI : http://dx.doi.org/10.13005/bbra/2294

ABSTRACT: The occurrence of toxicity in various organs was examined since volatile anesthetics have been used clinically. Among the complications the liver toxicity is very important. Due to the effects of N-Acetyl Cysteine (NAC), we decided to conduct a study to assess liver function in patients undergoing anesthesia with isoflurane and received NAC to evaluate its effects on the liver complications of these anesthetics. In this double-blind clinical trial, 68 patients between 20 to 60 years old candidate for elective surgery with a time duration between 1 to 3 hours (except surgeries on the liver and biliary tract) were enrolled and randomly divided into two groups, N-acetylcysteine and control. To check liver function, the levels of AST, ALT, LDH, PT, aPTT and INR was measured in the preoperative, 1 hour and 24 hours after surgery. The results of the study showed that there was significant difference between the levels of ALT (p=0.0001), AST (p=0.0001), and LDH (p=0.0001) between two groups. Heart rate was also significantly different between groups (p=0.0001) but the difference in systolic (p=0.096) and diastolic (p=0.174) blood pressure was not significant. N-acetyl cysteine is an antioxidant medication and its effects on excreting organs such as the kidneys and liver is frequently evaluated. In this study, n-acetyl cysteine could significantly reduce liver enzyme levels after administration of isoflurane, compared to the control group.

KEYWORDS: Key Words: Acetylcysteine, Isoflurane, Liver, Toxicity.

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