Volume 5, number 1
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Enos M. R. Kiremire¹, Likius, S. Daniel¹, Kelly Chibale²,Henry Kambafwile2 and Philip J. Rosenthal3

1Department of Chemistry, University of Namibia, Private Bag 133 01 (Namibia) 2Department of Chemistry University of Cape Town, Rondebosch 7701 (South Africa) 3Department of Medicine, San Fransisco General Hospital, San Francisco, California 94143 (USA)

ABSTRACT: Some sulphur-based ligands and their corresponding Cu(II) and Zn(II) complexes were tested in vitro against malaria parasite. The ligands were found to be devoid of biological activity. However, the corresponding metal complexes have been found to exhibit modest biological activity against the parasite when bound to Cu(II) and Zn(II) metal ions. On the other hand, the copper(II) complex containing a ligand with thiophenecarboxylic hydrazide fragment showed quite high biological activity towards the malaria parasite. This implies that the Cu(II) and Zn(II) metal ions induced the biological activity into the ligands in question.

KEYWORDS: Antimalarial; Sulphur based ligands; biological activity

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Kiremire E. M. R, Likius, Daniel S, Chibale K, Kambafwile H, Rosenthal P. J. Inducement of Antimalarial Biological Activity in Some S-Based Ligands by Cu(II) And Zn(II) Ions. Biosci Biotech Res Asia 2008;5(1).
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Kiremire E. M. R, Likius, Daniel S, Chibale K, Kambafwile H, Rosenthal P. J. Inducement of Antimalarial Biological Activity in Some S-Based Ligands by Cu(II) And Zn(II) Ions. Biosci Biotech Res Asia 2008;5(1).Available from: https://www.biotech-asia.org/?p=20080

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