Influence of Renal Sympathetic Denervation on Nitric Oxide-Induced Natriuresis and Diuresis

El-Sayed M. Kamel

Department of Pharmacology, Faculty of Medicine, 7th of October University, Misuratah, Libya.

ABSTRACT: Nitric oxide (NO) has been shown to influence kidney function by producing diuretic and naturutic effects . NO. also has been shown to modulate central and peripheral sympathetic activity . There for ,in order to investigate the possible role of renal sympathetic nerve on the renal effects of NO. , the effect of the No. donor, sodium nitropruoside ( SNP). Or the nitric oxide synthesis inhibitor (NOSI), IN-Nitro-l- arginin methyl ester ( L- NAME) on urine flow and renal sodium execration were studded in Sham kidney- denervated and bilaterally kidney-denervated water- loaded ethanol - anesthetized rats. In sham kidney – denervated rats, SNP. Produced significant increase urine flow and sodium execration. In contrast L- NAME caused significant reduction in urine flow and sodium execration . In kidney denervated rat ,SNP & L-NAME did not cause any significant change in the diuresis and natriuresis . This finding indicate that, the renal effects of NO. are mediated through inhibition of renal sympathetic nerves activity and thus ,has important role in regulating the neural component of renal function .

KEYWORDS: Nitric oxide; renal function; renal sympathetic nerves; Kidney-denervation

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