Hepatoprotective Activity of Colocasia Antiquorum Against Alcohol Induced Liver Injury In Rats

T. A. Tuse, U. N. Harle*, N.S.Vyawahare, V. V. Bore and P. R. Gangurde

Department of Pharmacology, AISSMS College of Pharmacy, Near R.T.O., Kennedy Road, Pune - 411 005 India.

Corresponding Author E-mail: unharle@yahoo.co.in

ABSTRACT: Colocasia antiquorum (L.) Schott, (Araceae), is an ancient crop grown throughout the humid tropics. The aim of this work was to study the hepatoprotective effect of crude ethanolic extract of corms of C. antiquorum using alcohol induced hepatotoxicity in rats as experimental models. The chronic treatment of extract of C. antiquorum at a dose of 500 mg/kg was administered orally for 21 days. The protective effect was evident from serum biochemical parameters and histopathological analysis. Rats treated with extract of C. antiquorum significantaly prevented the elevation of SGPT, SGOT, SALP, Cholesterol and Triglyceride in alcohol treated rats. Histopathological changes induced by alcohol were also significantly reduced by the extract treatment. The activity of ethanolic extract of C. antiquorum was nearly similar to that of silymarin, the reference hepatoprotective drug. Further it shows that the corms of C. antiquorum contains anthocyanins such as cyanidin 3-glucoside, pelargonidin 3-glucoside and cyanidin 3-rhamnoside, may be responsible for the hepatoprotective activity. Thus it may conclude that ethanolic extract of C. antiquorum possesses significant hepatoprotective properties.

KEYWORDS: Alcohol; Colocasia antiquorum; silymarin; ethanolic extract; anthocyanins

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