Antiulcer Effect of Commiphora Molmol Engl. (Burceraceae) Oleo-Gum-Resin and its Interaction With Ranitidine, As Demonstrated by Histological Studies

Abdul Rahman A. I. AL-Yahya

College of Applied Medical Sciences, Shaqra University, Saudi Arabia

DOI : http://dx.doi.org/10.13005/bbra/1859

ABSTRACT: Myrrh (Commiphora molmol Engl.) is a widely used herb throughout the world. The present study evaluates the ulcer healing effect of myrrh and effect of co-administration of myrrh with ranitidine on ulcer healing in acetic acid induced chronic gastric ulcers in rats. Myrrh was administered at two different doses of 500 mg/kg and 1000 mg/kg orally while ranitidine was given at a dose of 50 mg/kg orally. Myrrh increased the healing of the ulcers in a dose-dependent manner. It increased the ulcer score and ulcer index compared to vehicle treated animals. Histological studies of the ulcerated tissues supported the macroscopic findings as demonstrated by regeneration of surface epithelium. As expected, ranitidine increased gastric ulcer healing while the combination of ranitidine and high dose of myrrh (1000 mg/kg, p.o) showed increased ulcer healing compared to ranitidine alone. It was concluded that myrrh increases gastric ulcer healing and potentiates the effect of ranitidine on ulcer healing in rats.

KEYWORDS: myrrh; acetic acid; ulcer index; ulcer score

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