A Double Blind Study Comparing the Efficacy of Ibuprofen,Diclofena Sodium and Placebo on Lipid Peroxide- Malondialdehyde Levels In Gingival Tissue Before and after Periodontal Surgery

G. Balaji Babu¹,  A. Raja², R. Saranyan³, Majo Ambooken⁴, B. Manovijay⁵, J. Jaya Mary⁶

¹Professor, Department Of Periodontics, Csi Dental College,Madurai. ²Professor,Departmentof Orthodontics, Vinayaka Mission’s Sankarachariyar Dental College, Salem. ³Professor,Departmentof Periodontics, Vinayaka Mission’s Sankarachariyar Dental College, Salem. ⁴Professor and Hod,Department Of Periodontics, Marbaselios Dental College, Kothamangalam. ⁵Senior Lecturer,Department Of Periodontics, Vinayaka Mission’s Sankarachariyar Dental College, Salem. ⁶Post Graduate Student,Department Of Periodontics, Vinayaka Mission’s Sankarachariyar Dental College, Salem.

ABSTRACT: Recent data have demonstrated increased levels of malondialdehyde (MDA)in gingival tissues of patients suffering from chronic periodontitis.This study examined the efficacy of Ibuprofen, Diclofenac sodium and placebo on the malondialdehyde levels before and after periodontal surgery. A double blind study was conducted on 20 male patients. MDA levels were assessed by Nichans and Samuelson Biochemical analysis.Statistical analysis was done by Kruskall Wallis and Friedmans test and p values were obtained.   Mean pre and post-operative MDA levels were statistically significant at 1%. reduction in the levels of MDA following periodontal surgery were observed with the intake of both Ibuprofen and Diclofenac sodium than placebo.  

KEYWORDS: Diclofenac sodium; Ibuprofen; Malondialdehyde; periodontal surgery

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