Biomarker changes in Diabetic rats Treated with Ethanolic Plant Extract of Passiflora Foetida Linn.

Ravi Babu Birudu

Department of Zoology Aquaculture, Acharya Nagarjuna University, Guntur, A.P, India.

Corresponding Author E-mail: ravibabubiotech@gmail.com

DOI : http://dx.doi.org/10.13005/bbra/2465

ABSTRACT: The objective of this study was to evaluate the antidiabetic activity of Passiflora foetida in a model of dextrose -induced experimental diabetes in rats.Diabetes was induced in albino rats by administration of dextrose through feed. The ethanol extracts of Passiflora foetida at a dose of 500 and 250 mg/kg of body weight were administrated at a single dose per day to diabetes induced rats for a period of 14 days. The effect of ethanol extract of Passiflora foetida leaf extract on blood glucose, plasma insulin, creatinine, glycosylated haemoglobin, serum protein, , serum enzymes (serum glutamate pyruvate transaminases) , serum glutamate oxaloacetate transaminases, and alkaline phosphatase) were measured in the diabetic rats.Acute toxicity studies were conducted.The increased blood glucose, glycosylated haemoglobin and other biochemical parameters level were observed in diabetic rats treated with both doses of ethanol extract of leaf Passiflora foetida  compared to diabetic control rats. In diabetic rats, ethanol extract of  Passiflora foetida  leaf administration, altered the biochemical parameters were in diabetic control rats.Ethanol extract of Ethanol extract of Passiflora foetida  leaf possesses significant antidiabetic activity in diabetic rats.

KEYWORDS: Biomarker; Diabetes; Dextrose; SGOT, SGPT; Passiflora foetida

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