Volume 14, number 3
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Formulation and Characterization of Kaffir Lime Oil Nanoemulsion

Ghea Putri Christy1, Dewa Ayu Arimurni2, Made Dwi Pradipta Wahyudi2, Ronny Martien3 and Woro Anindito Sri Tunjung1

1 Laboratory of  Biochemistry, Faculty of Biology, Universitas Gadjah Mada, Jalan Teknika Selatan, Sekip Utara, Yogyakarta 55281, Indonesia.

2School of Pharmacy Mahaganesha, Jalan Tukad Barito Timur No. 57, Renon, Denpasar Selatan, Denpasar, Bali 80226, Indonesia.

3Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.

Corresponding Author E-mail: wanindito@ugm.ac.id

DOI : http://dx.doi.org/10.13005/bbra/2525

ABSTRACT: Kaffir lime oil has many health benefits. However, an obstacle to its commercial use is oxidation during storage. Nanoemulsions (particulate colloidal systems) have been shown to be suitable carriers for lipophilic essential oil constituents due to amphipathic compounds that facilitate solubility. The objectives of this study were to formulate thermodynamically stable kaffir lime oil nanoemulsions and to investigate their physicochemical properties. Air-dried leaves of kaffir lime were subjected to steam distillation to obtain essential oil. Preparation of nanoemulsions was done using the spontaneous emulsification method. Tween 80 and propylene glycol were selected as surfactant mix components. The oil phase consisted of Miglyol 812 as a carrier oil for kaffir lime oil while double-distilled water was used in the aqueous phase. The best formula with transmittance above 95% and highest essential oil content was selected. It contained 20% of Tween 80, 10% of propylene glycol, 1.25% Miglyol 812, and 3.75% kaffir lime essential oil. This formula was then characterized and its thermodynamic stability determined. . The results showed that kaffir lime oil nanoemulsions were thermodynamically stable and robustly withstood variations in temperature, centrifugation, and long-term storage. Additionally, the nanoemulsions had low viscosity, which may facilitate its development as a pharmaceutical compound.

KEYWORDS: essential oil; kaffir lime;kaffir lime; Nanoemulsions;  spontaneous emulsification

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Christy G. P, Arimurni D. A, Wahyudi M. D. P, Martien R, Tunjung W. A. S. Formulation and Characterization of Kaffir Lime Oil Nanoemulsion. Biosci Biotech Res Asia 2017;14(3).
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Christy G. P, Arimurni D. A, Wahyudi M. D. P, Martien R, Tunjung W. A. S. Formulation and Characterization of Kaffir Lime Oil Nanoemulsion. Biosci Biotech Res Asia 2017;14(3). Available from: https://www.biotech-asia.org/?p=26797

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