Molecular Targeted Therapy for Breast Cancer: A New Frontiers

Osama Al-Amer¹, Atif Abdulwahab A. Oyouni², and Shalini Saggu²

¹Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.

²Department of Biology, Faculty of Sciences, University of Tabuk, Tabuk, Saudi Arabia.

Corresponding Author Email: oalamer@ut.edu.sa

DOI : http://dx.doi.org/10.13005/bbra/2529

ABSTRACT: Cancer has become a major public health problem worldwide. Researches focus on the new approaches for cancer treatments that involve the specific targets of the cancer disease. Breast cancer is the most frequent type of cancer among women, and it causes approximately 25% of the deaths in women below the age of 35. Multiple environmental and hereditary factors are responsible for breast cancer such as age, family history, postmenopausal obesity, early menarche, late menopause, alcohol consumption, pregnancy and the use of exogenous hormones. Treatment of breast cancer patients relies primarily on surgery followed by radiotherapy and systemic therapy. Several molecules expressed and secreted by breast cancer cells have been identified by their interactions, invasion and metastasis. These molecular interactions appear to maintain the cancer cells’ survival and growth. The improvement in understanding of the molecular basis of breast cancer will provide possible targets for novel therapies. Therefor, this review focuses on the molecular and cellular basis of the breast cancer treatment.

KEYWORDS: Breast cancer;  prevention; radiation systemic therapy therapy;

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