Cytogenotoxic Effects of Ferula asafoetida as Homoeopathic Drug in Vicia faba

Sangeeta Dayal¹, Alka Noopur¹ and Harshal Kumar²  

¹Department of Bio-TechnologyMonad University, N.H-24, Delhi Hapur Road P.O. Pilkhuwa-245304, Distt- Hapur (U.P.) India.

²National Bureau of Plant Genetic Resources; IARI PUSA; New Delhi.

Corresponding Author E-mail: sangeetadayal2009@gmail.com

DOI : http://dx.doi.org/10.13005/bbra/2647

ABSTRACT: Extract of Ferula asafoetida (Heeng) is commonly used as Homoeopathic drug to cure various stomach related problems. There has been significant controversy associated with the side effects of Homoeopathic drugs. The effects of different concentrations of heeng on the chromosomes of Vicia faba was investigated. 5%, 10%, 20% & 30% of Ferula asafoetida were used for 4hrs, 8hrs, 12hrs and 24 hrs followed by acetocarmine squash procedure. All the concentrations showed mitoinhibitory effect in root tips of Vicia faba and also observed  so many chromosomal aberrations (clastogenic). The most observed aberrations were sticky chromosomes, chromatin bridges, chromatin fragments and laggards at every stage of mitotic division . The result of present study clearly established the cytogenotoxic behaviour of heeng as Homoeopathic drug.

KEYWORDS: Clastogenic; Cytogenotoxic; Ferula Asafoetida; Homoeopathic Drug; Vicia faba

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