Association Study of Candidate Gene Uncoupling Protein 2 (UCP2) with Type 2 Diabetes Mellitus in the Different Population Groups of Jammu Region

Sunil Raina¹ and Roopali Fotra²  

¹University of Jammu, Gujarbasti, Jammu, Jammu and Kashmir-180006-India.

²Institute of Human Genetics, University of Jammu-180006, India.

Corresponding Author E-mail: roopali_sidhharth@yahoo.co.in

DOI : http://dx.doi.org/10.13005/bbra/2751

ABSTRACT: Diabetes Mellitus is a group of metabolic disorders characterized by hyperglycaemic resulting from the defects of insulin secretion, insulin action or both. The present study was conducted in order to know the molecular genetic cause of the T₂DM patients belonging to the Jammu region of J&K State. Many genes have been known to be linked with the onset and progression of the T₂DM therefore the present data represents the role of one of the genes Uncoupling protein 2 (UCP2) known to be strongly associated with T₂DM was selected. A total of 250 confirmed cases & controls samples belonging to four population groups (Hindu, Muslim, Sikh & Christians) of Jammu region were also screened for UCP2 -866G/A promoter polymorphism (rs659366). The allelic odds ratio (OR) as observed for UCP2 -866G/A polymorphism in the four population groups showed significant association with Muslim & Sikh population groups. The study undertaken supports the findings of the previous investigations and thus is an addition to the existing literatute in support of UCP2 and T₂DM.

KEYWORDS: Diabetes Mellitus; Polymorphism and UCP2

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