Bacteriocidal Study Of Mixed Ligand Complexes Of Pyrazine Carboxamide And Isonicotinic Acid Hydrazide

Sangeeta Jain

Department of Biochemistry, Peoples Dental Academy, Bhopal (India)

ABSTRACT: Pyrazine carboxamide and isonicotinic acid hydrazide are commonly known as Pyrazinamide and Isoniazide respectively. They are antitubercular drugs effective against Mycobacterium tuberculosis of human type resistant, but is ineffective against the bonine and typical forms of tubercle bacilli. The drug shows antituberculosis activity in vitro at an acidic pH and is effective only against tubercle bacilli within macrophages. It is observed that when Pyrazinamide administered alone was almost as effective as isoniazid for the first two months but when both the drugs were given together, the effect was appreciably greater than with either drug alone. Further, it was compared with the effect of mixed ligand complexes of Pyrazinamide. Isoniazid and metals, the antitubercular study revealed an effective increase in potency of INH and PZA when chelated with Mn, Cd and Ca.

KEYWORDS: Mixed ligand; Antitubercular activity; pyrazinamide; Isoniazid

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