Can Gut Microbiota Modulation Could Reduce the Signs and Complications of COVID-19?

Mahmoud M. Elalfy¹ and Mona G. El-Hadidy²

¹Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Mansoura University, Egypt

²Medical Physiology, Faculty of Medicine, Mansoura University, Egypt

Corresponding Author E-mail : mahmoudelalfy@mans.edu.eg

DOI : http://dx.doi.org/10.13005/bbra/2825

ABSTRACT: In recently published articles, the digestive symptoms are common in patients with COVID-19 with evidence of hepatic failure. To better understand the role of modulation of GUT microbiota to reduce the signs and complications of COVID-19 infection. Zinc and Chloroquine could potentially contribute to changes in the gut flora and in some cases could reduce clinical signs in patients suffering the COVID-19 infection. Notably, the gut microbiota of neonates could resist COVID-19 as it essential for reducing numbers of iNKT cells in the intestine, and iNKT cells have been implicated in mediating allergic responses in the lungs. The circulating short-chain fatty acids (SCFAs), resulting from microbiota metabolism of the fiber, could have ameliorative effect to allergic inflammation in the lung that similarly occur in COVID-19 infection. Taken collectively, the modulation of gut microbiota is very important for improvement of immune system and protection against viral infection and reduction of clinical signs but further investigation is needed to study clinical available data from different global countries.

KEYWORDS: COVID-19 Infection; Drugs; Inkt Cells; Gut Microbiota

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