A Comparative Study of Total Albumin and Calcium Level between Preeclamptic Women Undergoing Magnesium Sulfate Therapy and with Normal Pregnancies

Elham Askary^1*,Fatemeh Emami¹, Fatemeh Sadat Najib², Tahereh Poordast², Mojdeh Momtahan²

¹Chief resident of obstetrics and gynecology, OB GYN department, Faghihi Hospital, Shiraz, Iran ²Associated Professor in obstetrics and gynecology, Shiraz University of Medical Sciences, Shiraz, Iran

DOI : http://dx.doi.org/10.13005/bbra/1879

ABSTRACT: Magnesium sulfate is used for seizure therapy and profilaxy in women with eclampsia and preeclampsia worldwide. Magnesium has effect on calcium modulation and also there are antithesis reports about alternation between magnesium sulfate therapy and decreased serum calcium level. Decreased in serum calcium level may cause some complications. The present study determines whether maternal serum level of calcium and albumin in patients with preeclampsia are lower than matched control subjects. Thirty patients with preeclampsia who were candidate for received magnesium sulfate therapy compared with 30 normal pregnant women as a control group. Serum calcium and albumin concentration were determined in 3 ml of venous blood sample that was taken before magnesium sulfate therapy, during and 24 hrs after discontinuation of  therapy in preeclamptic women and also before and 8 hrs after delivery in normal pregnant women. Findings show no significance difference of maternal and gestational ages between the two groups. The change in mean concentration of albumin, total calcium level, and corrected serum calcium level was observed just significantly at the albumin level 24 hrs after the termination of therapy in preeclamptic group (3 mg/dl, 2.7 mg/dl) P=0.03. There is no any correlation between others items in two groups. In both two groups serum calcium level is more before delivery than after. In the preeclamptic group (9.1 mg/dl, 9 mg/dl) P=0.00 and in normotensive group (9.3 mg/dl, 9 mg/dl) P=0.00. According to this small group study magnesium sulfate therapy in preeclamptic women doesn’t redounded to change in serum calcium level, but may lead to increased albumin level after delivery in control subject and also after discontinuation of the therapy in patients groups respectively.

KEYWORDS: Preeclampsia; Calcium; Albumin; Magnesium sulfate

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