Azoles Used in Agriculture as Possible Cause of Azole-Resistance in Clinical Candida Isolates
Hardeep Kaur1* Anamika Yadav1, Khushbu Wadhwa1, Kusum Jain1 and Soma M Ghorai2
1Department of Zoology, Ramjas College, University of Delhi, Delhi, India
2Department of Zoology, Hindu College, University of Delhi, Delhi, India
Corresponding Author E.mail: hardeepkaur@ramjas.du.ac.in
DOI : http://dx.doi.org/10.13005/bbra/2884
ABSTRACT: Agricultural azoles are preferred antifungals used by farmers due to their high efficiency against broad range of plant diseases like leaf rust, leaf spots, and powdery mildews. The past few decades have witnessed an unprecedented rise in their usage for crop protection. These compounds can thrive in environment for several months and being fungistatic in nature, can cause imbalance in the ecology of fungal species in the environment. Further their heavy use can lead to contamination and residues in plants, water, soil, and development of human health risk. These azoles share the similar mode of action and structural properties with medical azoles that are used for the treatment of fungal infections. Recent years have also seen an exceptional surge in the number of multi-drug resistant nosocomial Candida infections, especially in immuno compromised patients. The present review is an attempt to show the plausible mechanism of cross resistance among Candida isolates to agricultural and medical azoles. The study highlights the requirement of thorough scrutiny of usage of azoles both in medicine and agriculture.
KEYWORDS: Amphotericin; Cross-resistance; Echinocandin; Fluconazole
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Copy the following to cite this article: Kaur H, Yadav A, Wadhwa K, Jain K, Ghorai S. M. Azoles Used in Agriculture as Possible Cause of Azole-Resistance in Clinical Candida Isolates. Biosci Biotech Res Asia 2020;17(4). |
Copy the following to cite this URL: Kaur H, Yadav A, Wadhwa K, Jain K, Ghorai S. M. Azoles Used in Agriculture as Possible Cause of Azole-Resistance in Clinical Candida Isolates. Biosci Biotech Res Asia 2020;17(4). Available from: https://bit.ly/39TVkHy |