Preventive Effects of Dietaryraisins on Steroid - Induced Bone Changes in Rats

Al-Qtaitat Aiman^1*, Al-Dalaien Said² , Albtoosh Amal¹and Fardous Karawya¹

¹Department of Anatomy and Histology, Faculty of Medicine, Mutah University, Jordan

²Department of Pharmacology, Faculty of Medicine, Mutah University, Jordan

Correspondent Author Email: aimanaq@mutah.edu.jo

DOI : http://dx.doi.org/10.13005/bbra/2886

ABSTRACT:

Glucocorticoids is the most common cause of secondary osteoporosis. Osteoporosis is widespread, costly and causes pain, deformity and disability. Several studies report health benefits of raisins. Raisins have a combination of compounds with antibacterial, antioxidant,anticarcinogenic and anti-inflammatory properties. The present study investigated the impact of Raisins onmethylprednisolone-induced osteoporosis in rats. Thirty male albino rats were randomly divided into three main groups, ten rats each. Group I control group; Group II, osteoporotic group, where osteoporosis was induced by injection of methylprednisolone; Group III, protected group, animals were given raisinsconcomitant daily with methylprednisolone. Bone biochemical markers were assisted, hydroxyproline, urinary calcium excretion, serum calcium, alkaline phosphatase and osteocalcin. In addition to histological findings in lumbar vertebrae of the rats.Our findings showed that raisin has a positive osteoprotective effects on methylprednisolone induced bone changes histologically and over the biomarkers examined.This study suggests that dietary raisins may moderate methylprednisolone bone induced changes.

KEYWORDS: Alkaline Phosphatase; Hydroxyproline; Methylprednisolone; Osteoporosis; Osteocalcin; Raisins

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