Antimicrobial Activities of Schiff Base Metal Complexes of First Transition Series

Esmat Laiq¹ and Nida Shahid²*

¹Chemistry Section, Women’s College, Department of chemistry, Aligarh Muslim University, Aligarh, India– 202002

²Department of chemistry, Arya Mahilla (P.G.) College, Shahjahanpur, India,-242001

Corresponding Author E-mail: khanchemamu@gmail.com

DOI : http://dx.doi.org/10.13005/bbra/2941

ABSTRACT: The correlative antimicrobial analysis of amino acid Schiff base and derivatized tren metal complexes: A= [MLCl₂], B= [ML(CH₃OH)₂], respectively, against fungal strains, Candida parapsilosis, Candida albicans, Candida krusei, and Cryptococcus neoformans and (Gram-negative) P. aeruginosa,  E. coli, S. typhimurium, and S. pyogenes, Methicillin-resistant Staphylococcus aureus (MRSA), S. mutans (Gram-positive) bacterial strains had been done by disk diffusion method following McFarland protocol. [CuLCl₂] and [Cu (CH₃OH)₂] manifest overwhelming activity against microbes than other metal complexes of cobalt, nickel and zinc. Minimum inhibition concentration data also shows that copper complexes have the lowest MIC values against these tested microorganisms. The significance of this investigation is to uncover shielding and constructive therapeutic agents that wield against bacterial and fungal infection.

KEYWORDS: Antibacterial; Disk Diffusion Method; Minimum Inhibitory Concentration (MIC); l-leucine; Schiff base; Thiophene 2-carboxaldehyde

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