Effect of Extract of Uria Picta Jacq. on Experimentally Induced Hypertension in Wistar Rats

Pavan Bhausaheb Udvant¹ , Shubham Jagdish Khairnar^2*, Ghansham Balakrishn Jadhav¹, Rahul Ramakant Sable¹ and Mourya Krishnakumar Arprit¹

¹Department of Pharmacology, MVP’s College of Pharmacy, MVP campus, Gangapur Road, Nashik, Affiliated to S.P. Pune University, (M.S.), India.

²Department of Pharmacology, MET’S Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nashik, Maharashtra, Nashik.

Corresponding Author E-mail: shubhamkiop@gmail.com

DOI : http://dx.doi.org/10.13005/bbra/2937

ABSTRACT: Many allopathic medicines demand to remedy for hypertension but fail to fulfill the purpose, because of side effects and high cost. Herbal medicine does not cause side effects and natural herbs are completely safe. Rational and purpose of this study was to see how effective Uraria picta. Jacq. (U.P) extract was on experimentally induced hypertension in rats. The purpose of this research was to explore if U. Picta could be utilized as a curative or preventative medicine, as well as to investigate U. Picta possible toxicity in these animals. Blood pressure was elevated by Angiotensin II (150 ug/kg, i.p) in rats that is hypertensive condition. Animals were divided into groups as follow Group I (control) - vehicle, Group II Angiotensin II (150µgkg), Group III Angiotensin II extract low dose (100mgkg), Group IV-Angiotensin II extract middle dose (200mgkg), Group V-Angiotensin II extract (400mg/kg), Group VI – (Angiotensin II Telmisartan0.8mg/kg). and dosed as per protocol. Blood pressure was monitored with the noninvasive techniques (NIBP) using Power lab (AD instrument) Australia. Effect of extracts was studied on various oxidative stress markers like SOD, CAT, LOP and NO. as per observation extract of U. picta of high dose (400mg/kg BW p.o) had shown significant alteration in endogenous antioxidant entities i.e., SOD, CAT, LPO and also reduced NO level indicate antioxidant property of U. Picta. Same of above dose also reduced blood pressure and ACE level. So, from the above outcome we can consider that U.Picta extract may be having antioxidant and  antihypertensive activity.

KEYWORDS: Angiotensin-II; ACE; Catalase; Hypertension; Oxidative Stress; Uraria picta. jacq

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