Volume 18, number 4
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Quercetin Modulates Behavioural and Biochemical Alterations in Stressed Mice

Anthony Taghogho Eduviere1, Emuesiri Goodies Moke1, Adrian Itivere Omogbiya1, Lily Oghenevovwero Otomewo1*, Juliet Nnenda Olayinka2, Faith Eninidiere Aboyewa1 and Atare Peace Ijeje1

1Department of Pharmacology, Delta State University, Abraka, Nigeria.

2Department of Pharmacology, AfeBabalola University, Ado-Ekiti, Nigeria.

Corresponding Author E-mail: ejirukomaotomewo@gmail.com

DOI : http://dx.doi.org/10.13005/bbra/2951

ABSTRACT:

Disruption of the active phase of sleep alters the physiological homeostasis of the body and results in oxidative breakdown which may trigger a wide array of defects. The central nervous system and the metabolic system are some of the most affected systems as described in several literatures. Some plant based compounds with antioxidant property have been previously described in the abrogation of the deleterious effects of active sleep disruption. One of such compounds is quercetin. This study was premeditated to expatiate on the probable neuroprotective effect of quercetin on mice exposed to 72hr active sleep disruption. Mice were allotted into five treatment groups (n = 6): group 1 served as control, group 2 received 10 mL/kg vehicle, groups 3 and 4 received 25 and 50 mg/kg quercetin respectively, and group 5 received 50 mg/kg astaxanthin. Treatment lasted for 7 days while groups 2-5 were exposed to the sleep deprivation protocol starting from day 4. Behavioural tests followed by biochemical assays and histopathological changes in the prefrontal cortex were evaluated. Data were analysed by ANOVA set at p<0.05 significance. The results revealed that quercetin, in both doses, significantly amplified memory performance, attenuated depression-like behaviour, replenished catalase and superoxide dismutase, attenuated nitric oxide levels in brain and liver of mice when compared to control group and protected against loss of prefrontal cortex neurons. In conclusion, quercetin possesses protective effects against sleep deprivation-induced brain damage.

KEYWORDS: Antioxidants; Hepatoprotective; Liver; Neuroprotective; Oxidative stress; Quercetin

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Eduviere A. T, Moke E. G, Omogbiya A. I, Otomewo L. O, Olayinka J. N, Aboyewa F. E, Ijeje A. P. Quercetin Modulates Behavioural and Biochemical Alterations in Stressed Mice. Biosci Biotech Res Asia 2021;18(4).
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Eduviere A. T, Moke E. G, Omogbiya A. I, Otomewo L. O, Olayinka J. N, Aboyewa F. E, Ijeje A. P. Quercetin Modulates Behavioural and Biochemical Alterations in Stressed MiceBiosci Biotech Res Asia 2021;18(4). Available from: https://bit.ly/3GiSJE2

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