Formulation Development and Evaluation of Floating Tablets of Zolmitriptan
Sapana Ahirrao1*, Deepak Bhambere1
, Kunal Todkar1
, Moreshwar Patil1
, Pallavi Khairnar1
, Pavan Udavant1
, Piyushgir Gosavi1
, Anagha Baviskar2
1MET’s Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nashik, Maharashtra, India-422003.
2Assistant Professor at PRES's College of pharmacy (for women), chincholi, Nashik. PRES's College of pharmacy (for women), chincholi, Nashik.
Corresponding Author E-mail: sapana.58ahirrao@gmail.com
DOI : http://dx.doi.org/10.13005/bbra/2994
ABSTRACT:
Zolmitriptan is the antimigraine agent widely used for the treatment of the migraine. It shows the half-life of 2.5 – 3 h which indicate the frequent dosing to achieve proper pharmacological action of the drug. Gastro Retentive Drug Delivery System (GRDDS) is a common approach to decrease the dosing frequency and increase patient compliance, and delivery of drug through such an approach of floating tablet formulation will meet the requirement. This system showed substantial effect on the drug release through floating and swelling properties. The tablets were formulated by using direct compression technique along with hydrophilic polymers and gas generating system. In the preliminary trials, we observed that the tablets were within pharmacopeial limit. % Drug release of the formulations (F1 – F9) was studied up to 6 h and it was found from 52 to 91 %. The cumulative percentage drug release was inversely proportional to polymer concentrations of HPMC K100 M and PVP K 30. The batches follow Higuchi model of drug release which involves the diffusion mechanism. In-vitro dissolution studies showed good percent drug release, which is in accordance with robinson-errikson equation. Good buoyancy for additional 6 h, trailed by the diffusion.
KEYWORDS: Floating Tablet; Gastro Retention; HPMC K 100M; Migraine; Zolmitriptan
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Copy the following to cite this article: Ahirrao S, Bhambere D, Todkar K, Patil M, Khairnar P, Udavant P, Gosavi P, Baviskar A. Formulation Development and Evaluation of Floating Tablets of Zolmitriptan. Biosci Biotech Res Asia 2022;19(2). |
Copy the following to cite this URL: Ahirrao S, Bhambere D, Todkar K, Patil M, Khairnar P, Udavant P, Gosavi P, Baviskar A. Formulation Development and Evaluation of Floating Tablets of Zolmitriptan. Biosci Biotech Res Asia 2022;19(2). Available from: https://bit.ly/3NDIIFn |