Volume 19, number 2
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Gene-Specific Drug Delivery System: An Art of War

Neetu R. Saudagar, Sahebrao S. Boraste, Dattatray M. Shinkar , Prashant L. Pingale* and Sunil V. Amrutkar

Gokhale Education Society’s Sir Dr. M. S. Gosavi College of Pharmaceutical Education and Research, Nashik-422005, India.

Corresponding Author E-mail: prashant.pingale@gmail.com

DOI : http://dx.doi.org/10.13005/bbra/3000

ABSTRACT:

Drug delivery key research aim is to support patients by designing clinically effective formulations. Drug delivery systems can enhance the treatment of a variety of diseases, including microbes’ infections, and cancers. Drug delivery systems preparation methods, on the other hand, remain difficult, particularly at the microscale. Some of the necessary criteria for speeding the transformation of drug delivery systems from a limited scale to an enormous scale include reducing batch-to-batch variance and increasing production volume. Gene-specific drug delivery system has a bright future as a preventive solution to severe diseases and has developed as an influential tool in recent years as a unique technology for disease management. Gene silencing, protein expression, or gene repair may be used to cure perhaps every illness with a gene-specific delivery system. The genetic material must be paired with a delivery additive to successfully transfer the nucleic acid payload to its target tissue. There are various non-viral and viral vectors involved along with the different mechanisms of gene entry into a cell which is discussed in this article. This review highlights that the gene-specific drug delivery system has vast scope in therapy and can prove advantageous over other therapies, because it includes several carriers and different methods of plasma membrane permeation. Very interestingly, it also includes various applications of the gene-specific drug delivery system in several diseases and recent trends in the Coronavirus vaccine.

KEYWORDS: Chitosan; Cancer; Dendrimers; COVID-19; Transfection; Viral and Non-viral vectors

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Saudagar N. R, Boraste S. S, Shinkar D. M, Pingale P. L, Amrutkar S. V. Gene-Specific Drug Delivery System: An Art of War. Biosci Biotech Res Asia 2022;19(2).
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Saudagar N. R, Boraste S. S, Shinkar D. M, Pingale P. L, Amrutkar S. V. Gene-Specific Drug Delivery System: An Art of War. Biosci Biotech Res Asia 2022;19(2). Available from: https://bit.ly/3xWUkhy

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