The Effect of Temperature on the Critical Micelle Concentration and Micellar Solubilization of Poorly Water Soluble Drugs

Manoj Jangde^1*, S. K. Chatterjee², Monika Jain³, Sanjay Ghosh⁴, Rajendra Jangde⁵ and Deepak Sinha⁴

¹Government Naveen College, Birgaon, Pt. Ravishankar Shukla University, Raipur (C.G.)-492003,India

²Government M.V.P.G. College, Mahasamund(C.G.)-493554, India

³Government Polytechnic Bhatapara (C.G.)-493118, India

⁴Government Nagarjuna Post Graduate College of Science, Raipur (C.G.)-492010, India

⁵University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, India.

Corresponding Author e-mail: manojjangde1982@gmail.com

DOI : http://dx.doi.org/10.13005/bbra/3054

ABSTRACT: Non-ionic surfactants, poly oxyethylene sorbitan adipose acid esters (polysorbate), were used in this work to explore the consequence of temperature on CMC throughout a wide temperature range. The phase separation model is used to analyze the enthalpy and entropy of micelle conformation. The Du Nöuys ring was used to determine the results' face pressure. The CMC standards were derived after the strong break down in surfactant attention plots of face pressure vs. logarithms. The CMC at continuous temperature decreases as the chain length of the surfactants rises, which is completely connected to the reduction in hydrophilicity of the motes. Because of the lower possibility of hydrogen bond conformation on high temperatures, the CMC of each surfactant initially declines and then increases as the system temperature rises. As the temperature rises, the commencement of micellization tends to happen at a faster rate. The focus of this research is on the characterization of solubilization of drugs that aren't sufficiently responsive. Face pressure measurements for nonionic surfactant TritonX-100 were also taken in order to assess the solubilization features. In the presence of colourful organic detergent, the medium's opposition and the likely positions of SMX and TMP were also discussed. TritonX-100, a nonionic surfactant, was also tested. In the presence of colourful organic detergents, the medium's opposition and the likely position of SMX and TMP were also discussed.

KEYWORDS: Ciprofloxacin; Effect of Temperature; Surfactant; Solubilization

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