Formulation and Evaluation of Herbal Ointment of Berberis aristata for Inhibition of Psoriasis-like Symptoms

Alankar Shrivastav^1* , Arun Kumar Mishra¹ and Ashessh Kumar Gupta²

¹Department of Pharmacology, Pharmacy Academy, IFTM University, Moradabad, India

²School of Pharmaceutical Sciences, IFTM University, Moradabad, India

Corresponding Author E-mail: alankar1994.ss@gmail.com

DOI : http://dx.doi.org/10.13005/bbra/3046

ABSTRACT: To prepare an herbal ointment using an ethanolic extract of Berberis aristata and assess the anti-psoriatic effectiveness of the finished product. We were able to make multiple ointments that were each categorized as F-1, F-2, and F-3 by adding varying concentrations of stearic acid and cetyl alcohol by learning about various formulation types, such as oil in water. The analysis of many factors, including pH, viscosity, spreadability, and stability, was used to evaluate all formulations. A formulation of ethanolic extract (F-3) showed antipsoriatic action. No evidence of a separate phase or ease of removal was found in any of the formations, but they all demonstrated good spreadability, consistency, appearance, and pH. Additionally, during irritancy trials, the formulation F-3 did not cause redness, oedema, erythema, or irritation. The use of this formulation on the skin is safe. As a result, the study implies that the extract's and the ointment's base's compositions are safer and more stable, however, they might also have synergistic effects.

KEYWORDS: Antipsoriatic; Berberis aristata; Ethanolic extract; Formulation; Ointment

[ HTML Full Text]