Recent Advances in Analytical Method Development and Validation Techniques for Anti-HIV Pharmaceuticals of Tenofovir

Shweta Avhad^1*, Vidya Morkar¹, Sagar Shinde¹, Chaitanya patki¹, Hemant Chikhale² and Laxmikant Borse³

¹Department of Post Graduate Study in Quality Assurance, Sandip Institute of Pharmaceutical Sciences, Affiliated to Savitribai Phule Pune University Mahiravani, Nashik-422213, MS, India

²Department of Pharmaceutical Chemistry, Sandip Institute of Pharmaceutical Sciences, Affiliated to Savitribai Phule Pune University, Mahiravani, Nashik-422213, MS, India.

³Department of Pharmacology, Sandip Institute of Pharmaceutical Sciences, Affiliated to Savitribai Phule Pune University, Mahiravani, Nashik-422213, MS, India

Corresponding Author E-mail:avhad.shwetaa@gmail.com

DOI : http://dx.doi.org/10.13005/bbra/3099

ABSTRACT: Many questions have been raised regarding the management of acquired immunodeficiency syndrome (AIDS) which is caused by a retrovirus called as HIV, (human immunodeficiency virus) is what causes AIDS. Infection caused by HIV is particularly the world's most serious health and development challenges. Although there is no known complete cure for HIV, several drugs can help you stay healthy by lowering the amount of HIV in your body. When treating HIV infection, antiretroviral therapy is used, and a variety of medications are available from this category. Tenofovir and its salt versions, both by themselves and in combination with emtricitabine, are the most often utilized medications. HIV levels should be lowered so that your immune system can function more effectively. This article offers a summary and evaluation of several analytical techniques used on the antiretroviral medication tenofovir over the previous five years. It covers forced degradation, HPLC and RP-HPLC, HPTLC, UPLC and RP-UPLC, LC-MS.

KEYWORDS: AIDS; Analytical techniques; Antiretroviral; HIV; HPLC; Tenofovir

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