Diamagnetic Zn(II) and Hg(II) Complexes with Fluconazole: Synthesis, Spectral Characterization and Biological Investigation

P. Keerthika^1*,  S. Balasubramaniyan¹ and R. Govindharaju²

¹Department of Chemistry, Government Arts College (Affiliated to Bharathidasan University, Tiruchirappalli), Ariyalur-621713, Tamil Nadu, India.

²Department of Chemistry, Thanthai Hans Roever College (Autonomous), (Affiliated to Bharathidasan University, Tiruchirappalli), Perambalur - 621 220, Tamil Nadu, India.

Corresponding Author E-mail: lathika.ttp@gmail.com

DOI : http://dx.doi.org/10.13005/bbra/3122

ABSTRACT: In order to create new mononuclear diamagnetic complexes (M = Zn (II) and Hg (II)), fluconazole and thiocyanate ion ligands were utilized. Physicochemical and spectroscopic approaches were used to describe the synthesized metal complexes. The spectral data show that the fluconazole served as a bidentate ligand and linked to metal ions via the nitrogen of the imine group, the thiocyanate ion connected to metal ions through nitrogen. The antibacterial capacities of the strains of Candida albicans (MTCC 183) for fungi and Escherichia coli (MTCC 732) for bacteria were assessed using the disc diffusion method. The results showed that Zn (II) and Hg (II) complexes have much stronger antibacterial activity than pure ligands because of metal chelation. The complexes interactions with the stable free radical DPPH are measured. The free radical scavenging activities of the complexes and the ligand have been determined by measuring their interaction with the stable free radical DPPH. The complexes have larger antioxidant activity as compared to the ligands.

KEYWORDS: Antimicrobial; Diamagnetic; Fluconazole; Thiocyanate ion

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